Separase activity distribution can be a marker of major molecular response and proliferation of CD34(+) cells in TKI-treated chronic myeloid leukemia patients

Separase, a cysteine endopeptidase, is a key player in mitotic sister chromatid separation, replication fork dynamics, and DNA repair. Aberrant expression and/or altered separase proteolytic activity are associated with aneuploidy, tumorigenesis, and disease progression. Since genomic instability an...

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Detalles Bibliográficos
Autores principales: Spiess, Birgit, Kleiner, Helga, Flach, Johanna, Fabarius, Alice, Saussele, Susanne, Hofmann, Wolf-Karsten, Seifarth, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196950/
https://www.ncbi.nlm.nih.gov/pubmed/32253454
http://dx.doi.org/10.1007/s00277-020-04007-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196950/
https://www.ncbi.nlm.nih.gov/pubmed/32253454
http://dx.doi.org/10.1007/s00277-020-04007-4

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