Autophagy promotes mammalian survival by suppressing oxidative stress and p53

Autophagy captures intracellular components and delivers them to lysosomes for degradation and recycling. Conditional autophagy deficiency in adult mice causes liver damage, shortens life span to 3 mo due to neurodegeneration, and is lethal upon fasting. As autophagy deficiency causes p53 induction...

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Detalles Bibliográficos
Autores principales: Yang, Yang, Karsli-Uzunbas, Gizem, Poillet-Perez, Laura, Sawant, Akshada, Hu, Zhixian Sherrie, Zhao, Yuhan, Moore, Dirk, Hu, Wenwei, White, Eileen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197357/
https://www.ncbi.nlm.nih.gov/pubmed/32193353
http://dx.doi.org/10.1101/gad.335570.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197357/
https://www.ncbi.nlm.nih.gov/pubmed/32193353
http://dx.doi.org/10.1101/gad.335570.119

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