The cytotoxicity of gallium maltolate in glioblastoma cells is enhanced by metformin through combined action on mitochondrial complex 1

New drugs are needed for glioblastoma, an aggressive brain tumor with a dismal prognosis. We recently reported that gallium maltolate (GaM) retards the growth of glioblastoma in a rat orthotopic brain tumor model by inhibiting mitochondrial function and iron-dependent ribonucleotide reductase (RR)....

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Detalles Bibliográficos
Autores principales: Alhajala, Hisham S., Markley, John L., Kim, Jin Hae, Al-Gizawiy, Mona M., Schmainda, Kathleen M., Kuo, John S., Chitambar, Christopher R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197450/
https://www.ncbi.nlm.nih.gov/pubmed/32391122
http://dx.doi.org/10.18632/oncotarget.27567

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197450/
https://www.ncbi.nlm.nih.gov/pubmed/32391122
http://dx.doi.org/10.18632/oncotarget.27567

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