Opposing patterns of abnormal D1 and D2 receptor dependent cortico-striatal plasticity explain increased risk taking in patients with DYT1 dystonia

Patients with DYT1 dystonia caused by the mutated TOR1A gene exhibit risk neutral behaviour compared to controls who are risk averse in the same reinforcement learning task. It is unclear whether this behaviour can be linked to changes in cortico-striatal plasticity demonstrated in animal models whi...

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Detalles Bibliográficos
Autores principales: Gilbertson, Tom, Arkadir, David, Steele, J. Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197855/
https://www.ncbi.nlm.nih.gov/pubmed/32365120
http://dx.doi.org/10.1371/journal.pone.0226790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197855/
https://www.ncbi.nlm.nih.gov/pubmed/32365120
http://dx.doi.org/10.1371/journal.pone.0226790

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