Metabolism and Effects on Endogenous Metabolism of Paracetamol (Acetaminophen) in a Porcine Model of Liver Failure

The metabolic fate, toxicity, and effects on endogenous metabolism of paracetamol (acetaminophen, APAP) in 22 female Landrace cross large white pigs were evaluated in a model of acute liver failure (ALF). Anesthetized pigs were initially dosed at 250 mg/kg via an oroduodenal tube with APAP serum con...

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Detalles Bibliográficos
Autores principales: Dargue, Rebecca, Zia, Rabiya, Lau, Chungho, Nicholls, Andrew W, Dare, Theo O, Lee, Karla, Jalan, Rajiv, Coen, Muireann, Wilson, Ian D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Biotransformation, Toxicokinetics, and Pharmacokinetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197950/
https://www.ncbi.nlm.nih.gov/pubmed/32061126
http://dx.doi.org/10.1093/toxsci/kfaa023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197950/
https://www.ncbi.nlm.nih.gov/pubmed/32061126
http://dx.doi.org/10.1093/toxsci/kfaa023

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