A functional polymorphism in the paired basic amino acid-cleaving enzyme 4 gene confers osteoarthritis risk in a population of Eastern China

Paired basic amino acid-cleaving enzyme 4 (PACE4), a proprotein convertase, is involved in the activation of aggrecanases (ADAMTS-4 and ADAMTS-5) in osteoarthritic and cytokine-stimulated cartilage. Activated aggrecanases cause aggrecan degradation and thus, contribute to osteoarthritis (OA). In thi...

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Detalles Bibliográficos
Autores principales: He, Jin, Yang, Haoyu, Xu, Zhonghua, Li, Jin, Chen, Gang, Jiang, Lifeng, Wu, Lidong, Zhou, Xindie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2020
Materias:
Human and Medical Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197988/
https://www.ncbi.nlm.nih.gov/pubmed/32167127
http://dx.doi.org/10.1590/1678-4685-GMB-2019-0115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197988/
https://www.ncbi.nlm.nih.gov/pubmed/32167127
http://dx.doi.org/10.1590/1678-4685-GMB-2019-0115

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