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A functional polymorphism in the paired basic amino acid-cleaving enzyme 4 gene confers osteoarthritis risk in a population of Eastern China

Paired basic amino acid-cleaving enzyme 4 (PACE4), a proprotein convertase, is involved in the activation of aggrecanases (ADAMTS-4 and ADAMTS-5) in osteoarthritic and cytokine-stimulated cartilage. Activated aggrecanases cause aggrecan degradation and thus, contribute to osteoarthritis (OA). In thi...

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Detalles Bibliográficos
Autores principales:	He, Jin, Yang, Haoyu, Xu, Zhonghua, Li, Jin, Chen, Gang, Jiang, Lifeng, Wu, Lidong, Zhou, Xindie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Sociedade Brasileira de Genética 2020
Materias:	Human and Medical Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197988/ https://www.ncbi.nlm.nih.gov/pubmed/32167127 http://dx.doi.org/10.1590/1678-4685-GMB-2019-0115

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