Engineered scPDL1-DM1 drug conjugate with improved in vitro analysis to target PD-L1 positive cancer cells and intracellular trafficking studies in cancer therapy

Antibody-drug conjugates (ADC), precisely deliver a cytotoxic agent to antigen-expressing tumor cells by using specific binding strategies of antibodies. The ADC has shown the ability of potent bio-therapeutics development but indefinite stoichiometric linkage and full-length antibody penetration co...

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Detalles Bibliográficos
Autores principales: Kalim, Muhammad, Wang, Shenghao, Liang, Keying, Khan, Muhammad Saleem Iqbal, Zhan, Jinbiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2020
Materias:
Human and Medical Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198028/
https://www.ncbi.nlm.nih.gov/pubmed/31967634
http://dx.doi.org/10.1590/1678-4685-GMB-2018-0391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198028/
https://www.ncbi.nlm.nih.gov/pubmed/31967634
http://dx.doi.org/10.1590/1678-4685-GMB-2018-0391

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