Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons

Olfactory receptor neurons (ORNs) use odour-induced intracellular cAMP surge to gate cyclic nucleotide-gated nonselective cation (CNG) channels in cilia. Prolonged exposure to cAMP causes calmodulin-dependent feedback-adaptation of CNG channels and attenuates neural responses. On the other hand, the...

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Detalles Bibliográficos
Autores principales: Nakashima, Noriyuki, Nakashima, Kie, Taura, Akiko, Takaku-Nakashima, Akiko, Ohmori, Harunori, Takano, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198493/
https://www.ncbi.nlm.nih.gov/pubmed/32366818
http://dx.doi.org/10.1038/s41467-020-15917-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198493/
https://www.ncbi.nlm.nih.gov/pubmed/32366818
http://dx.doi.org/10.1038/s41467-020-15917-2

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