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Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons
Olfactory receptor neurons (ORNs) use odour-induced intracellular cAMP surge to gate cyclic nucleotide-gated nonselective cation (CNG) channels in cilia. Prolonged exposure to cAMP causes calmodulin-dependent feedback-adaptation of CNG channels and attenuates neural responses. On the other hand, the...
Autores principales: | Nakashima, Noriyuki, Nakashima, Kie, Taura, Akiko, Takaku-Nakashima, Akiko, Ohmori, Harunori, Takano, Makoto |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198493/ https://www.ncbi.nlm.nih.gov/pubmed/32366818 http://dx.doi.org/10.1038/s41467-020-15917-2 |
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