ATR Inhibition Broadly Sensitizes Soft-Tissue Sarcoma Cells to Chemotherapy Independent of Alternative Lengthening Telomere (ALT) Status

Only few drugs have shown activity in patients with advanced soft-tissue and the median overall survival is only 18 months. Alterations of genes involved in the DNA damage repair pathway have been associated with sarcoma risk and prognosis. ATR plays a crucial role in maintaining genomic integrity b...

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Detalles Bibliográficos
Autores principales: Laroche-Clary, Audrey, Chaire, Vanessa, Verbeke, Stéphanie, Algéo, Marie-Paule, Malykh, Andrei, Le Loarer, François, Italiano, Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198496/
https://www.ncbi.nlm.nih.gov/pubmed/32366852
http://dx.doi.org/10.1038/s41598-020-63294-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198496/
https://www.ncbi.nlm.nih.gov/pubmed/32366852
http://dx.doi.org/10.1038/s41598-020-63294-z

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