The circular RNA FAM169A functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR-583 and BTRC

Intervertebral disc degeneration (IDD) is an important factor leading to low back pain, although the underlying mechanisms remain poorly understood. In this study we examined the role of circular RNA FAM169A (circ-FAM169A) in degenerative nucleus pulposus (NP) tissues, and validated its function in...

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Autores principales: Guo, Wei, Mu, Kun, Zhang, Bin, Sun, Chao, Zhao, Ling, Dong, Zhan-Yin, Cui, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198574/
https://www.ncbi.nlm.nih.gov/pubmed/32366862
http://dx.doi.org/10.1038/s41419-020-2543-8
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author Guo, Wei
Mu, Kun
Zhang, Bin
Sun, Chao
Zhao, Ling
Dong, Zhan-Yin
Cui, Qing
author_facet Guo, Wei
Mu, Kun
Zhang, Bin
Sun, Chao
Zhao, Ling
Dong, Zhan-Yin
Cui, Qing
author_sort Guo, Wei
collection PubMed
description Intervertebral disc degeneration (IDD) is an important factor leading to low back pain, although the underlying mechanisms remain poorly understood. In this study we examined the role of circular RNA FAM169A (circ-FAM169A) in degenerative nucleus pulposus (NP) tissues, and validated its function in cultured human NP cells. Overexpression of circ-FAM169A in NP cells markedly enhanced extracellular matrix (ECM) catabolism and suppressed ECM anabolism in NP cells. Furthermore, circ-FAM169A sequestered miR-583, which could potentially upregulate BTRC, an inducer of the NF-κB signaling pathway. In conclusion, the present study revealed that circ-FAM169A promotes IDD development via miR-583/BTRC signaling. These findings provide a potential therapeutic option for the treatment of IDD.
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spelling pubmed-71985742020-05-05 The circular RNA FAM169A functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR-583 and BTRC Guo, Wei Mu, Kun Zhang, Bin Sun, Chao Zhao, Ling Dong, Zhan-Yin Cui, Qing Cell Death Dis Article Intervertebral disc degeneration (IDD) is an important factor leading to low back pain, although the underlying mechanisms remain poorly understood. In this study we examined the role of circular RNA FAM169A (circ-FAM169A) in degenerative nucleus pulposus (NP) tissues, and validated its function in cultured human NP cells. Overexpression of circ-FAM169A in NP cells markedly enhanced extracellular matrix (ECM) catabolism and suppressed ECM anabolism in NP cells. Furthermore, circ-FAM169A sequestered miR-583, which could potentially upregulate BTRC, an inducer of the NF-κB signaling pathway. In conclusion, the present study revealed that circ-FAM169A promotes IDD development via miR-583/BTRC signaling. These findings provide a potential therapeutic option for the treatment of IDD. Nature Publishing Group UK 2020-05-04 /pmc/articles/PMC7198574/ /pubmed/32366862 http://dx.doi.org/10.1038/s41419-020-2543-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Guo, Wei
Mu, Kun
Zhang, Bin
Sun, Chao
Zhao, Ling
Dong, Zhan-Yin
Cui, Qing
The circular RNA FAM169A functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR-583 and BTRC
title The circular RNA FAM169A functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR-583 and BTRC
title_full The circular RNA FAM169A functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR-583 and BTRC
title_fullStr The circular RNA FAM169A functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR-583 and BTRC
title_full_unstemmed The circular RNA FAM169A functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR-583 and BTRC
title_short The circular RNA FAM169A functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR-583 and BTRC
title_sort circular rna fam169a functions as a competitive endogenous rna and regulates intervertebral disc degeneration by targeting mir-583 and btrc
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198574/
https://www.ncbi.nlm.nih.gov/pubmed/32366862
http://dx.doi.org/10.1038/s41419-020-2543-8
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