Cargando…

Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities

Emerging urinary biomarkers continue to show promise in evaluating lupus nephritis (LN). Here, we screen urine from active LN patients for 1129 proteins using an aptamer-based platform, followed by ELISA validation in two independent cohorts comprised of 127 inactive lupus, 107 active LN, 67 active...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stanley, Samantha, Vanarsa, Kamala, Soliman, Samar, Habazi, Deena, Pedroza, Claudia, Gidley, Gabriel, Zhang, Ting, Mohan, Shree, Der, Evan, Suryawanshi, Hemant, Tuschl, Thomas, Buyon, Jill, Putterman, Chaim, Mok, Chi Chiu, Petri, Michelle, Saxena, Ramesh, Mohan, Chandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198599/ https://www.ncbi.nlm.nih.gov/pubmed/32366845 http://dx.doi.org/10.1038/s41467-020-15986-3

Ejemplares similares

Author Correction: Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities
por: Stanley, Samantha, et al.
Publicado: (2020)

Single-cell RNA sequencing for the study of lupus nephritis
por: Der, Evan, et al.
Publicado: (2019)

Association of Urine sCD163 With Proliferative Lupus Nephritis, Fibrinoid Necrosis, Cellular Crescents and Intrarenal M2 Macrophages
por: Zhang, Ting, et al.
Publicado: (2020)

Exploring urine:serum fractional excretion ratios as potential biomarkers for lupus nephritis
por: Soliman, Samar A., et al.
Publicado: (2022)

Urine VCAM-1 as a marker of renal pathology activity index in lupus nephritis
por: Singh, Sandeep, et al.
Publicado: (2012)

Urine ALCAM, PF4 and VCAM-1 Surpass Conventional Metrics in Identifying Nephritis Disease Activity in Childhood-Onset Systemic Lupus Erythematosus
por: Soliman, Samar A., et al.
Publicado: (2022)

Urine L-selectin reflects clinical and histological renal disease activity and treatment response in lupus nephritis across multi-ethnicity
por: Shen, Yiwei, et al.
Publicado: (2023)

Corrigendum: Urine L-selectin reflects clinical and histological renal disease activity and treatment response in lupus nephritis across multi-ethnicity
por: Shen, Yiwei, et al.
Publicado: (2023)

ALCAM and VCAM-1 as urine biomarkers of activity and long-term renal outcome in systemic lupus erythematosus
por: Parodis, Ioannis, et al.
Publicado: (2020)

Proteomics in rheumatology: the dawn of a new era
por: Vanarsa, Kamala, et al.
Publicado: (2010)

Gender Differences in the Pathogenesis and Outcome of Lupus and of Lupus Nephritis
por: Schwartzman-Morris, Julie, et al.
Publicado: (2012)

Insulin-Like Growth Factor Binding Protein-4 as a Marker of Chronic Lupus Nephritis
por: Wu, Tianfu, et al.
Publicado: (2016)

The role of anti-α-actinin antibodies in the pathogenesis and monitoring of lupus nephritis
por: Youinou, Pierre, et al.
Publicado: (2009)

Tubular Cell and Keratinocyte Single-cell Transcriptomics Applied to Lupus Nephritis Reveal Type I IFN and Fibrosis Relevant Pathways
por: Der, Evan, et al.
Publicado: (2019)

Urinary pro-thrombotic, anti-thrombotic, and fibrinolytic molecules as biomarkers of lupus nephritis
por: Qin, Ling, et al.
Publicado: (2019)

The CD6/ALCAM pathway promotes lupus nephritis via T cell–mediated responses
por: Chalmers, Samantha A., et al.
Publicado: (2022)

Lupus nephritis: current update
por: Saxena, Ramesh, et al.
Publicado: (2011)

Cell atlas of the foetal human heart and implications for autoimmune-mediated congenital heart block
por: Suryawanshi, Hemant, et al.
Publicado: (2020)

Comprehensive proteomics and platform validation of urinary biomarkers for bladder cancer diagnosis and staging
por: Vanarsa, Kamala, et al.
Publicado: (2023)

Correction to: Urinary pro-thrombotic, anti-thrombotic, and fibrinolytic molecules as biomarkers of lupus nephritis
por: Qin, Ling, et al.
Publicado: (2019)

Urinary angiostatin, CXCL4 and VCAM-1 as biomarkers of lupus nephritis
por: Mok, Chi Chiu, et al.
Publicado: (2018)

Predicting disease course in ulcerative colitis using stool proteins identified through an aptamer-based screen
por: Soomro, Sanam, et al.
Publicado: (2021)

Comprehensive Urinomic Identification of Protein Alternatives to Creatinine Normalization for Diagnostic Assessment of Lupus Nephritis
por: Soomro, Sanam, et al.
Publicado: (2022)

Inflammation associated anemia and ferritin as disease markers in SLE
por: Vanarsa, Kamala, et al.
Publicado: (2012)

Erythrocyte-bound C4d in combination with complement and autoantibody status for the monitoring of SLE
por: Merrill, Joan T, et al.
Publicado: (2018)

4336 Renal Tubular Complement C9 Deposition is Associated with Renal Tubular Damage and Fibrosis in Lupus Nephritis
por: Wang, Shudan, et al.
Publicado: (2020)

Leukocyte Beta-Catenin Expression Is Disturbed in Systemic Lupus Erythematosus
por: Orme, Jacob J., et al.
Publicado: (2016)

Low Dose Epigallocatechin Gallate Alleviates Experimental Colitis by Subduing Inflammatory Cells and Cytokines, and Improving Intestinal Permeability
por: Du, Yong, et al.
Publicado: (2019)

Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus
por: Hutcheson, Jack, et al.
Publicado: (2012)

Urine proteomic insights from the belimumab in lupus nephritis trial
por: Weeding, Emma, et al.
Publicado: (2022)

Metabolic Disturbances Associated with Systemic Lupus Erythematosus
por: Wu, Tianfu, et al.
Publicado: (2012)

Discovery of Novel Circulating Immune Complexes in Lupus Nephritis Using Immunoproteomics
por: Tang, Chenling, et al.
Publicado: (2022)

Reduction in erythrocyte-bound complement activation products and titres of anti-C1q antibodies associate with clinical improvement in systemic lupus erythematosus
por: Buyon, Jill, et al.
Publicado: (2016)

Mammalian miRNA curation through next-generation sequencing
por: Brown, Miguel, et al.
Publicado: (2013)

Epigallocatechin-3-Gallate Dampens Non-Alcoholic Fatty Liver by Modulating Liver Function, Lipid Profile, and Macrophage Polarization
por: Du, Yong, et al.
Publicado: (2021)

Quantitative proteomic screening uncovers candidate diagnostic and monitoring serum biomarkers of ankylosing spondylitis
por: Hwang, Mark, et al.
Publicado: (2023)

Bradykinin 1 receptor blockade subdues systemic autoimmunity, renal inflammation, and blood pressure in murine lupus nephritis
por: Qin, Ling, et al.
Publicado: (2019)

Baseline Elevations of Leukotriene Metabolites and Altered Plasmalogens Are Prognostic Biomarkers of Plaque Progression in Systemic Lupus Erythematosus
por: Baig, Sahar, et al.
Publicado: (2022)

Autoimmune reactivity to malondialdehyde adducts in systemic lupus erythematosus is associated with disease activity and nephritis
por: Hardt, Uta, et al.
Publicado: (2018)

Resistin, Elastase, and Lactoferrin as Potential Plasma Biomarkers of Pediatric Inflammatory Bowel Disease Based on Comprehensive Proteomic Screens
por: Louis Sam Titus, Anto Sam Crosslee, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_nsk2nmbsrtk8fov1r54plnfv3m