Side chain effect in the modulation of α(v)β(3)/α(5)β(1) integrin activity via clickable isoxazoline-RGD-mimetics: development of molecular delivery systems

Construction of small molecule ligand (SML) based delivery systems has been performed starting from a polyfunctionalized isoxazoline scaffold, whose α(v)β(3) and α(5)β(1) integrins’ potency has been already established. The synthesis of this novel class of ligands was obtained by conjugation of link...

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Detalles Bibliográficos
Autores principales: Ferrazzano, Lucia, Corbisiero, Dario, Potenza, Eleonora, Baiula, Monica, Dattoli, Samantha Deianira, Spampinato, Santi, Belvisi, Laura, Civera, Monica, Tolomelli, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198601/
https://www.ncbi.nlm.nih.gov/pubmed/32366988
http://dx.doi.org/10.1038/s41598-020-64396-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198601/
https://www.ncbi.nlm.nih.gov/pubmed/32366988
http://dx.doi.org/10.1038/s41598-020-64396-4

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