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Side chain effect in the modulation of α(v)β(3)/α(5)β(1) integrin activity via clickable isoxazoline-RGD-mimetics: development of molecular delivery systems
Construction of small molecule ligand (SML) based delivery systems has been performed starting from a polyfunctionalized isoxazoline scaffold, whose α(v)β(3) and α(5)β(1) integrins’ potency has been already established. The synthesis of this novel class of ligands was obtained by conjugation of link...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198601/ https://www.ncbi.nlm.nih.gov/pubmed/32366988 http://dx.doi.org/10.1038/s41598-020-64396-4 |