Efficient correction of a deleterious point mutation in primary horse fibroblasts with CRISPR-Cas9

Phenotypic selection during animal domestication has resulted in unwanted incorporation of deleterious mutations. In horses, the autosomal recessive condition known as Glycogen Branching Enzyme Deficiency (GBED) is the result of one of these deleterious mutations (102C > A), in the first exon of...

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Detalles Bibliográficos
Autores principales: Pinzon-Arteaga, Carlos, Snyder, Matthew D., Lazzarotto, Cicera R., Moreno, Nicolas F., Juras, Rytis, Raudsepp, Terje, Golding, Michael C., Varner, Dickson D., Long, Charles R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198616/
https://www.ncbi.nlm.nih.gov/pubmed/32366884
http://dx.doi.org/10.1038/s41598-020-62723-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198616/
https://www.ncbi.nlm.nih.gov/pubmed/32366884
http://dx.doi.org/10.1038/s41598-020-62723-3

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