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Efficient correction of a deleterious point mutation in primary horse fibroblasts with CRISPR-Cas9
Phenotypic selection during animal domestication has resulted in unwanted incorporation of deleterious mutations. In horses, the autosomal recessive condition known as Glycogen Branching Enzyme Deficiency (GBED) is the result of one of these deleterious mutations (102C > A), in the first exon of...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198616/ https://www.ncbi.nlm.nih.gov/pubmed/32366884 http://dx.doi.org/10.1038/s41598-020-62723-3 |