Highly Efficient Base Editing in Viral Genome Based on Bacterial Artificial Chromosome Using a Cas9-Cytidine Deaminase Fused Protein

Viruses evolve rapidly and continuously threaten animal health and economy, posing a great demand for rapid and efficient genome editing technologies to study virulence mechanism and develop effective vaccine. We present a highly efficient viral genome manipulation method using CRISPR-guided cytidin...

Descripción completa

Detalles Bibliográficos
Autores principales: Zheng, Ke, Jiang, Fang-Fang, Su, Le, Wang, Xin, Chen, Yu-Xin, Chen, Huan-Chun, Liu, Zheng-Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198655/
https://www.ncbi.nlm.nih.gov/pubmed/31792738
http://dx.doi.org/10.1007/s12250-019-00175-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198655/
https://www.ncbi.nlm.nih.gov/pubmed/31792738
http://dx.doi.org/10.1007/s12250-019-00175-4

Ejemplares similares