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Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the downstream stimulator of interferon genes (STING) acting as essential immune-surveillance mediators have become hot topics of research. The intrinsic function of the cGAS-STING pathway facilitates type-I interferon (IFN...

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Detalles Bibliográficos
Autores principales: Wan, Dongshan, Jiang, Wei, Hao, Junwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198750/
https://www.ncbi.nlm.nih.gov/pubmed/32411126
http://dx.doi.org/10.3389/fimmu.2020.00615
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author Wan, Dongshan
Jiang, Wei
Hao, Junwei
author_facet Wan, Dongshan
Jiang, Wei
Hao, Junwei
author_sort Wan, Dongshan
collection PubMed
description Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the downstream stimulator of interferon genes (STING) acting as essential immune-surveillance mediators have become hot topics of research. The intrinsic function of the cGAS-STING pathway facilitates type-I interferon (IFN) inflammatory signaling responses and other cellular processes such as autophagy, cell survival, senescence. cGAS-STING pathway interplays with other innate immune pathways, by which it participates in regulating infection, inflammatory disease, and cancer. The therapeutic approaches targeting this pathway show promise for future translation into clinical applications. Here, we present a review of the important previous works and recent advances regarding the cGAS-STING pathway, and provide a comprehensive understanding of the modulatory pattern of the cGAS-STING pathway under multifarious pathologic states.
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spelling pubmed-71987502020-05-14 Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response Wan, Dongshan Jiang, Wei Hao, Junwei Front Immunol Immunology Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the downstream stimulator of interferon genes (STING) acting as essential immune-surveillance mediators have become hot topics of research. The intrinsic function of the cGAS-STING pathway facilitates type-I interferon (IFN) inflammatory signaling responses and other cellular processes such as autophagy, cell survival, senescence. cGAS-STING pathway interplays with other innate immune pathways, by which it participates in regulating infection, inflammatory disease, and cancer. The therapeutic approaches targeting this pathway show promise for future translation into clinical applications. Here, we present a review of the important previous works and recent advances regarding the cGAS-STING pathway, and provide a comprehensive understanding of the modulatory pattern of the cGAS-STING pathway under multifarious pathologic states. Frontiers Media S.A. 2020-04-28 /pmc/articles/PMC7198750/ /pubmed/32411126 http://dx.doi.org/10.3389/fimmu.2020.00615 Text en Copyright © 2020 Wan, Jiang and Hao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wan, Dongshan
Jiang, Wei
Hao, Junwei
Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response
title Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response
title_full Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response
title_fullStr Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response
title_full_unstemmed Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response
title_short Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response
title_sort research advances in how the cgas-sting pathway controls the cellular inflammatory response
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198750/
https://www.ncbi.nlm.nih.gov/pubmed/32411126
http://dx.doi.org/10.3389/fimmu.2020.00615
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