RNA-Seq-Based TCR Profiling Reveals Persistently Increased Intratumoral Clonality in Responders to Anti-PD-1 Therapy

Substantial effort is being invested in the search for peripheral or intratumoral T cell receptor (TCR) repertoire features that could predict the response to immunotherapy. Here we demonstrate the utility of MiXCR software for TCR and immunoglobulin repertoire extraction from RNA-Seq data obtained...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhigalova, Ekaterina A., Izosimova, Anna I., Yuzhakova, Diana V., Volchkova, Lilia N., Shagina, Irina A., Turchaninova, Maria A., Serebrovskaya, Ekaterina O., Zagaynova, Elena V., Chudakov, Dmitriy M., Sharonov, George V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199218/
https://www.ncbi.nlm.nih.gov/pubmed/32411589
http://dx.doi.org/10.3389/fonc.2020.00385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199218/
https://www.ncbi.nlm.nih.gov/pubmed/32411589
http://dx.doi.org/10.3389/fonc.2020.00385

Ejemplares similares