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RNA-Seq-Based TCR Profiling Reveals Persistently Increased Intratumoral Clonality in Responders to Anti-PD-1 Therapy

Substantial effort is being invested in the search for peripheral or intratumoral T cell receptor (TCR) repertoire features that could predict the response to immunotherapy. Here we demonstrate the utility of MiXCR software for TCR and immunoglobulin repertoire extraction from RNA-Seq data obtained...

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Detalles Bibliográficos
Autores principales:	Zhigalova, Ekaterina A., Izosimova, Anna I., Yuzhakova, Diana V., Volchkova, Lilia N., Shagina, Irina A., Turchaninova, Maria A., Serebrovskaya, Ekaterina O., Zagaynova, Elena V., Chudakov, Dmitriy M., Sharonov, George V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199218/ https://www.ncbi.nlm.nih.gov/pubmed/32411589 http://dx.doi.org/10.3389/fonc.2020.00385

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