Inhibition of mast cell tryptase attenuates neuroinflammation via PAR-2/p38/NFκB pathway following asphyxial cardiac arrest in rats

BACKGROUND: Cardiac arrest survivors suffer from neurological dysfunction including cognitive impairment. Cerebral mast cells, the key regulators of neuroinflammation contribute to neuroinflammation-associated cognitive dysfunction. Mast cell tryptase was demonstrated to have a proinflammatory effec...

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Detalles Bibliográficos
Autores principales: Ocak, Umut, Eser Ocak, Pinar, Huang, Lei, Xu, Weilin, Zuo, Yuchun, Li, Peng, Gamdzyk, Marcin, Zuo, Gang, Mo, Jun, Zhang, Guangyu, Zhang, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199326/
https://www.ncbi.nlm.nih.gov/pubmed/32366312
http://dx.doi.org/10.1186/s12974-020-01808-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199326/
https://www.ncbi.nlm.nih.gov/pubmed/32366312
http://dx.doi.org/10.1186/s12974-020-01808-2

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