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Inhibition of mast cell tryptase attenuates neuroinflammation via PAR-2/p38/NFκB pathway following asphyxial cardiac arrest in rats

BACKGROUND: Cardiac arrest survivors suffer from neurological dysfunction including cognitive impairment. Cerebral mast cells, the key regulators of neuroinflammation contribute to neuroinflammation-associated cognitive dysfunction. Mast cell tryptase was demonstrated to have a proinflammatory effec...

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Detalles Bibliográficos
Autores principales:	Ocak, Umut, Eser Ocak, Pinar, Huang, Lei, Xu, Weilin, Zuo, Yuchun, Li, Peng, Gamdzyk, Marcin, Zuo, Gang, Mo, Jun, Zhang, Guangyu, Zhang, John H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199326/ https://www.ncbi.nlm.nih.gov/pubmed/32366312 http://dx.doi.org/10.1186/s12974-020-01808-2

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