A New Gorilla Adenoviral Vector with Natural Lung Tropism Avoids Liver Toxicity and Is Amenable to Capsid Engineering and Vector Retargeting

Human adenoviruses have many attractive features for gene therapy applications. However, the high prevalence of preexisting immunity against these viruses in general populations worldwide has greatly limited their clinical utility. In addition, the most commonly used human adenovirus, human adenovir...

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Detalles Bibliográficos
Autores principales: Lu, Zhi Hong, Dmitriev, Igor P., Brough, Douglas E., Kashentseva, Elena A., Li, Jie, Curiel, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Gene Delivery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199421/
https://www.ncbi.nlm.nih.gov/pubmed/32102889
http://dx.doi.org/10.1128/JVI.00265-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199421/
https://www.ncbi.nlm.nih.gov/pubmed/32102889
http://dx.doi.org/10.1128/JVI.00265-20

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