Cryo-EM reconstruction of a VPS13 fragment reveals a long groove to channel lipids between membranes

A single particle cryo-EM reconstruction of an ∼160-kD N-terminal fragment of the lipid transport protein VPS13 reveals an ∼160-Å long channel lined with hydrophobic residues suitable for solubilizing multiple lipid fatty acid moieties. The structure suggests that VPS13 and related proteins, like th...

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Detalles Bibliográficos
Autores principales: Li, PeiQi, Lees, Joshua Aaron, Lusk, C. Patrick, Reinisch, Karin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199853/
https://www.ncbi.nlm.nih.gov/pubmed/32182622
http://dx.doi.org/10.1083/jcb.202001161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199853/
https://www.ncbi.nlm.nih.gov/pubmed/32182622
http://dx.doi.org/10.1083/jcb.202001161

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