Nek2-mediated GAS2L1 phosphorylation and centrosome-linker disassembly induce centrosome disjunction

Centrosome disjunction occurs in late G2 to facilitate bipolar spindle formation and is mediated by the NIMA-related kinase Nek2. Here, we show that GAS2L1, a microtubule- and F-actin–binding protein required for centrosome disjunction, undergoes Nek2-mediated phosphorylation at Ser352 in G2/M. The...

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Detalles Bibliográficos
Autores principales: Au, Franco K.C., Hau, Bill K.T., Qi, Robert Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199859/
https://www.ncbi.nlm.nih.gov/pubmed/32289147
http://dx.doi.org/10.1083/jcb.201909094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199859/
https://www.ncbi.nlm.nih.gov/pubmed/32289147
http://dx.doi.org/10.1083/jcb.201909094

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