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Nek2-mediated GAS2L1 phosphorylation and centrosome-linker disassembly induce centrosome disjunction
Centrosome disjunction occurs in late G2 to facilitate bipolar spindle formation and is mediated by the NIMA-related kinase Nek2. Here, we show that GAS2L1, a microtubule- and F-actin–binding protein required for centrosome disjunction, undergoes Nek2-mediated phosphorylation at Ser352 in G2/M. The...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199859/ https://www.ncbi.nlm.nih.gov/pubmed/32289147 http://dx.doi.org/10.1083/jcb.201909094 |