A Mansonone Derivative Coupled with Monoclonal Antibody 4D5-Modified Chitosan Inhibit AKR1C3 to Treat Castration-Resistant Prostate Cancer

PURPOSE: Aldo-ketoreductase (AKR) 1C3 is crucial for testosterone synthesis. Abnormally high expression/activity of AKR1C3 can promote castration-resistant prostate cancer (CRPC). A mansonone derivative and AKR1C3 inhibitor, 6e, was combined with 4D5 (extracellular fragment of the monoclonal antibod...

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Detalles Bibliográficos
Autores principales: Zhou, Meng, Wang, Xiaoyu, Xia, Jie, Cheng, Yating, Xiao, Lichun, Bei, Yu, Tang, Jianzhong, Huang, Yadong, Xiang, Qi, Huang, Shiliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200237/
https://www.ncbi.nlm.nih.gov/pubmed/32431503
http://dx.doi.org/10.2147/IJN.S241324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200237/
https://www.ncbi.nlm.nih.gov/pubmed/32431503
http://dx.doi.org/10.2147/IJN.S241324

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