Hereditary hemochromatosis disrupts uric acid homeostasis and causes hyperuricemia via altered expression/activity of xanthine oxidase and ABCG2

Hereditary hemochromatosis (HH) is mostly caused by mutations in the iron-regulatory gene HFE. The disease is associated with iron overload, resulting in liver cirrhosis/cancer, cardiomegaly, kidney dysfunction, diabetes, and arthritis. Fe(2+)-induced oxidative damage is suspected in the etiology of...

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Detalles Bibliográficos
Autores principales: Ristic, Bojana, Sivaprakasam, Sathish, Narayanan, Monisha, Ganapathy, Vadivel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Molecular Bases of Health & Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200644/
https://www.ncbi.nlm.nih.gov/pubmed/32239172
http://dx.doi.org/10.1042/BCJ20190873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200644/
https://www.ncbi.nlm.nih.gov/pubmed/32239172
http://dx.doi.org/10.1042/BCJ20190873

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