Serum alpha-mannosidase as an additional barrier to eliciting oligomannose-specific HIV-1-neutralizing antibodies

Oligomannose-type glycans on HIV-1 gp120 form a patch that is targeted by several broadly neutralizing antibodies (bnAbs) and that therefore is of interest to vaccine design. However, attempts to elicit similar oligomannose-specific bnAbs by immunizing with oligomannosidic glycoconjugates have only...

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Detalles Bibliográficos
Autores principales: Bruxelle, Jean-François, Kirilenko, Tess, Qureshi, Quratulain, Lu, Naiomi, Trattnig, Nino, Kosma, Paul, Pantophlet, Ralph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200719/
https://www.ncbi.nlm.nih.gov/pubmed/32371950
http://dx.doi.org/10.1038/s41598-020-64500-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200719/
https://www.ncbi.nlm.nih.gov/pubmed/32371950
http://dx.doi.org/10.1038/s41598-020-64500-8

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