Small molecule inhibition of human cGAS reduces total cGAMP output and cytokine expression in cells

The cGAS-STING pathway is a major mechanism that mammalian cells utilize to detect cytoplasmic dsDNA from incoming viruses, bacteria, or self. CYCLIC GMP-AMP SYNTHASE (cGAS) is the sensor protein that directly binds dsDNAs. cGAS synthesizes cyclic GMP-AMP (cGAMP), which binds to the adaptor STIMULAT...

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Detalles Bibliográficos
Autores principales: Wiser, Caroline, Kim, Byungil, Vincent, Jessica, Ascano, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200739/
https://www.ncbi.nlm.nih.gov/pubmed/32371942
http://dx.doi.org/10.1038/s41598-020-64348-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200739/
https://www.ncbi.nlm.nih.gov/pubmed/32371942
http://dx.doi.org/10.1038/s41598-020-64348-y

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