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Tuning the Binding Affinity of Heme-Responsive Biosensor for Precise and Dynamic Pathway Regulation
Current challenge for dynamic pathway control in metabolic engineering is enabling the components of the artificial regulatory system to be tunable. Here, we designed and built a heme-responsive regulatory system containing a heme biosensor HrtR and CRISPRi to regulate chemicals production while mai...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200772/ https://www.ncbi.nlm.nih.gov/pubmed/32371371 http://dx.doi.org/10.1016/j.isci.2020.101067 |