Skeletal-Muscle Metabolic Reprogramming in ALS-SOD1(G93A) Mice Predates Disease Onset and Is A Promising Therapeutic Target

Patients with ALS show, in addition to the loss of motor neurons in the spinal cord, brainstem, and cerebral cortex, an abnormal depletion of energy stores alongside hypermetabolism. In this study, we show that bioenergetic defects and muscle remodeling occur in skeletal muscle of the SOD1(G93A) mou...

Descripción completa

Detalles Bibliográficos
Autores principales: Scaricamazza, Silvia, Salvatori, Illari, Giacovazzo, Giacomo, Loeffler, Jean Philippe, Renè, Frederique, Rosina, Marco, Quessada, Cyril, Proietti, Daisy, Heil, Constantin, Rossi, Simona, Battistini, Stefania, Giannini, Fabio, Volpi, Nila, Steyn, Frederik J., Ngo, Shyuan T., Ferraro, Elisabetta, Madaro, Luca, Coccurello, Roberto, Valle, Cristiana, Ferri, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200935/
https://www.ncbi.nlm.nih.gov/pubmed/32371370
http://dx.doi.org/10.1016/j.isci.2020.101087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200935/
https://www.ncbi.nlm.nih.gov/pubmed/32371370
http://dx.doi.org/10.1016/j.isci.2020.101087

Ejemplares similares