Loss-of-function polymorphism in IL6R reduces risk of JAK2V617F somatic mutation and myeloproliferative neoplasm: A Mendelian randomization study

BACKGROUND: Whether inflammation is independently associated with development of JAK2V617F mutation and myeloproliferative neoplasm is not clear. We tested the hypothesis that a loss-of-function polymorphism in IL6R (marked by rs4537545) reduces risk of JAK2V617F mutation and myeloproliferative neop...

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Detalles Bibliográficos
Autores principales: Pedersen, Kasper Mønsted, Çolak, Yunus, Ellervik, Christina, Hasselbalch, Hans Carl, Bojesen, Stig Egil, Nordestgaard, Børge Grønne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201035/
https://www.ncbi.nlm.nih.gov/pubmed/32382712
http://dx.doi.org/10.1016/j.eclinm.2020.100280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201035/
https://www.ncbi.nlm.nih.gov/pubmed/32382712
http://dx.doi.org/10.1016/j.eclinm.2020.100280

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