Cargando…

High Glucose Induces the Loss of Retinal Pericytes Partly via NLRP3-Caspase-1-GSDMD-Mediated Pyroptosis

Diabetic retinopathy (DR) is one of the hallmark complications of diabetes and a leading cause of vision loss in adults. Retinal pericyte death seems to be a prominent feature in the onset of DR. Pyroptosis is an inflammatory form of programmed cell death, defined as being caspase-gasdermin-D (GSDMD...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gan, Jinhua, Huang, Maomao, Lan, Genyin, Liu, Li, Xu, Fangyuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201508/ https://www.ncbi.nlm.nih.gov/pubmed/32420343 http://dx.doi.org/10.1155/2020/4510628

Ejemplares similares

HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells
por: Yao, Feng, et al.
Publicado: (2022)

Downregulated XBP-1 Rescues Cerebral Ischemia/Reperfusion Injury-Induced Pyroptosis via the NLRP3/Caspase-1/GSDMD Axis
por: Zhang, Yueting, et al.
Publicado: (2022)

Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer
por: Yan, Honglin, et al.
Publicado: (2021)

Puerarin Inhibits NLRP3-Caspase-1-GSDMD-Mediated Pyroptosis via P2X7 Receptor in Cardiomyocytes and Macrophages
por: Sun, Shuchan, et al.
Publicado: (2023)

Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer
por: Xie, Wei, et al.
Publicado: (2023)

Cold Stress Induced Liver Injury of Mice through Activated NLRP3/Caspase-1/GSDMD Pyroptosis Signaling Pathway
por: Liu, Yuanyuan, et al.
Publicado: (2022)

ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer
por: Su, Pingping, et al.
Publicado: (2023)

Ceramide induces pyroptosis through TXNIP/NLRP3/GSDMD pathway in HUVECs
por: Liu, Fangfang, et al.
Publicado: (2022)

β-sitosterol alleviates dextran sulfate sodium-induced experimental colitis via inhibition of NLRP3/Caspase-1/GSDMD-mediated pyroptosis
por: Zhang, Di, et al.
Publicado: (2023)

Emodin Alleviates High-Glucose-Induced Pancreatic β-Cell Pyroptosis by Inhibiting NLRP3/GSDMD Signaling
por: Xing, Yiqian, et al.
Publicado: (2022)

Moxibustion against Cyclophosphamide-Induced Premature Ovarian Failure in Rats through Inhibiting NLRP3-/Caspase-1-/GSDMD-Dependent Pyroptosis
por: Zhang, Cai-rong, et al.
Publicado: (2021)

NLRP3/caspase-1/GSDMD–mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression
por: Li, Shanshan, et al.
Publicado: (2021)

Berberine Reduces Renal Cell Pyroptosis in Golden Hamsters with Diabetic Nephropathy through the Nrf2-NLRP3-Caspase-1-GSDMD Pathway
por: Ding, Baozhu, et al.
Publicado: (2021)

Secoisolariciresinol diglucoside induces pyroptosis by activating caspase‐1 to cleave GSDMD in colorectal cancer cells
por: Chen, Tuo, et al.
Publicado: (2022)

Tetracaine hydrochloride induces macrophage pyroptosis through caspase‑1/11‑GSDMD signaling pathways
por: Zhang, Ran, et al.
Publicado: (2023)

Corrigendum to “Berberine Reduces Renal Cell Pyroptosis in Golden Hamsters with Diabetic Nephropathy through the Nrf2-NLRP3-Caspase-1-GSDMD Pathway”
por: Ding, Baozhu, et al.
Publicado: (2022)

Disulfiram alleviates pristane-induced lupus via inhibiting GSDMD-mediated pyroptosis
por: Zhuang, Lili, et al.
Publicado: (2022)

Trimetazidine attenuates dexamethasone-induced muscle atrophy via inhibiting NLRP3/GSDMD pathway-mediated pyroptosis
por: Wang, Li, et al.
Publicado: (2021)

Talaromyces marneffei activates the AIM2-caspase-1/-4-GSDMD axis to induce pyroptosis in hepatocytes
por: Wang, Gang, et al.
Publicado: (2022)

Calcitriol Alleviates Hyperosmotic Stress-Induced Corneal Epithelial Cell Damage via Inhibiting the NLRP3–ASC–Caspase-1–GSDMD Pyroptosis Pathway in Dry Eye Disease
por: Zhang, Jing, et al.
Publicado: (2021)

Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway
por: Jia, Yifan, et al.
Publicado: (2020)

Suppression of NLRP3/Caspase-1/GSDMD Mediated Corneal Epithelium Pyroptosis Using Melatonin-Loaded Liposomes to Inhibit Benzalkonium Chloride-Induced Dry Eye Disease
por: Lou, Qi, et al.
Publicado: (2023)

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity
por: Schneider, Katharina S., et al.
Publicado: (2017)

Ophiopogonin B alleviates cisplatin resistance of lung cancer cells by inducing Caspase-1/GSDMD dependent pyroptosis
por: Cheng, Ziyu, et al.
Publicado: (2022)

Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer
por: Teng, Jin-Feng, et al.
Publicado: (2020)

GSDMD contributes to myocardial reperfusion injury by regulating pyroptosis
por: Ye, Xiaomiao, et al.
Publicado: (2022)

Jinwujiangu Capsule Treats Fibroblast-Like Synoviocytes of Rheumatoid Arthritis by Inhibiting Pyroptosis via the NLRP3/CAPSES/GSDMD Pathway
por: Ling, Yi, et al.
Publicado: (2021)

Anti-Inflammation and Anti-Pyroptosis Activities of Mangiferin via Suppressing NF-κB/NLRP3/GSDMD Signaling Cascades
por: Feng, Min, et al.
Publicado: (2022)

Hemoglobin Derived from Subarachnoid Hemorrhage-Induced Pyroptosis of Neural Stem Cells via ROS/NLRP3/GSDMD Pathway
por: Yue, Tingting, et al.
Publicado: (2023)

Didymin Suppresses Microglia Pyroptosis and Neuroinflammation Through the Asc/Caspase-1/GSDMD Pathway Following Experimental Intracerebral Hemorrhage
por: Gu, Lingui, et al.
Publicado: (2022)

Puerarin protects renal ischemia-reperfusion injury in rats through NLRP3/Caspase-1/GSDMD pathway
por: Wang, Kangyu, et al.
Publicado: (2023)

Polygonatum sibiricum Polysaccharides Attenuate Lipopoly-Saccharide-Induced Septic Liver Injury by Suppression of Pyroptosis via NLRP3/GSDMD Signals
por: Xiao, Linxia, et al.
Publicado: (2022)

Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway
por: Yang, Ye, et al.
Publicado: (2020)

Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation
por: Wang, Yufang, et al.
Publicado: (2019)

GSDMD-mediated pyroptosis: a critical mechanism of diabetic nephropathy
por: Zuo, Yi, et al.
Publicado: (2021)

Mycobacterium tuberculosis PE_PGRS19 Induces Pyroptosis through a Non-Classical Caspase-11/GSDMD Pathway in Macrophages
por: Qian, Jianing, et al.
Publicado: (2022)

Myoglobin promotes macrophage polarization to M1 type and pyroptosis via the RIG-I/Caspase1/GSDMD signaling pathway in CS-AKI
por: Li, Ning, et al.
Publicado: (2022)

IRF2 contributes to myocardial infarction via regulation of GSDMD induced pyroptosis
por: Li, Yongxing, et al.
Publicado: (2022)

Ursolic Acid Alleviates Neuroinflammation after Intracerebral Hemorrhage by Mediating Microglial Pyroptosis via the NF-κB/NLRP3/GSDMD Pathway
por: Lei, Pan, et al.
Publicado: (2023)

GSDMD-Mediated Cardiomyocyte Pyroptosis Promotes Myocardial I/R Injury
por: Shi, Huairui, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nv3q4nq9js840qg3uq8fqvkm82