Targeted point mutations of the m(6)A modification in miR675 using RNA-guided base editing induce cell apoptosis

Methylation of the adenine base at the nitrogen 6 position (m(6)A) is the most common post-transcriptional epigenetic modification of RNA, and it plays a very important role in regulating gene expression. To investigate the role of m(6)A methylation in the expression of non-coding RNA and miRNA, we...

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Detalles Bibliográficos
Autores principales: Hao, Jindong, Li, Chengshun, Lin, Chao, Hao, Yang, Yu, Xianfeng, Xia, Yidan, Gao, Fei, Jiang, Ziping, Wang, Dongxu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201566/
https://www.ncbi.nlm.nih.gov/pubmed/32323721
http://dx.doi.org/10.1042/BSR20192933

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201566/
https://www.ncbi.nlm.nih.gov/pubmed/32323721
http://dx.doi.org/10.1042/BSR20192933

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