Downregulation of GLYR1 contributes to microsatellite instability colorectal cancer by targeting p21 via the p38MAPK and PI3K/AKT pathways

BACKGROUND: GLYR1 has a high mutation frequency in microsatellite instability colorectal cancer (MSI CRC) and is presumed to be a novel tumor suppressor. However, the role of GLYR1 in tumors has never been studied. In particular, the downregulation of GLYR1 in MSI CRC is worthy of further investigat...

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Detalles Bibliográficos
Autores principales: Hu, Zhiyan, Long, Ting, Ma, Yidan, Zhu, Jiaxian, Gao, Lingfang, Zhong, Yan, Wang, Xia, Wang, Xiaoyan, Li, Zuguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201645/
https://www.ncbi.nlm.nih.gov/pubmed/32370786
http://dx.doi.org/10.1186/s13046-020-01578-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201645/
https://www.ncbi.nlm.nih.gov/pubmed/32370786
http://dx.doi.org/10.1186/s13046-020-01578-y

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