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Downregulation of GLYR1 contributes to microsatellite instability colorectal cancer by targeting p21 via the p38MAPK and PI3K/AKT pathways

BACKGROUND: GLYR1 has a high mutation frequency in microsatellite instability colorectal cancer (MSI CRC) and is presumed to be a novel tumor suppressor. However, the role of GLYR1 in tumors has never been studied. In particular, the downregulation of GLYR1 in MSI CRC is worthy of further investigat...

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Detalles Bibliográficos
Autores principales:	Hu, Zhiyan, Long, Ting, Ma, Yidan, Zhu, Jiaxian, Gao, Lingfang, Zhong, Yan, Wang, Xia, Wang, Xiaoyan, Li, Zuguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201645/ https://www.ncbi.nlm.nih.gov/pubmed/32370786 http://dx.doi.org/10.1186/s13046-020-01578-y

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