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Constitutive activity of dopamine receptor type 1 (D1R) increases Ca(V)2.2 currents in PFC neurons

Alterations in dopamine receptor type 1 (D1R) density are associated with cognitive deficits of aging and schizophrenia. In the prefrontal cortex (PFC), D1R plays a critical role in the regulation of working memory, which is impaired in these cognitive deficit states, but the cellular events trigger...

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Detalles Bibliográficos
Autores principales: McCarthy, Clara Inés, Chou-Freed, Cambria, Rodríguez, Silvia Susana, Yaneff, Agustín, Davio, Carlos, Raingo, Jesica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201881/
https://www.ncbi.nlm.nih.gov/pubmed/32259196
http://dx.doi.org/10.1085/jgp.201912492