Ancestry and frequency of genetic variants in the general population are confounders in the characterization of germline variants linked to cancer

BACKGROUND: Pediatric high-grade gliomas (pHGGs) are incurable malignant brain cancers. Clear somatic genetic drivers are difficult to identify in the majority of cases. We hypothesized that this may be due to the existence of germline variants that influence tumor etiology and/or progression and ar...

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Detalles Bibliográficos
Autores principales: Bobyn, Anna, Zarrei, Mehdi, Zhu, Yuankun, Hoffman, Mary, Brenner, Darren, Resnick, Adam C., Scherer, Stephen W., Gallo, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201963/
https://www.ncbi.nlm.nih.gov/pubmed/32375678
http://dx.doi.org/10.1186/s12881-020-01033-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201963/
https://www.ncbi.nlm.nih.gov/pubmed/32375678
http://dx.doi.org/10.1186/s12881-020-01033-x

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