Small‐molecule inhibition of aging‐associated chromosomal instability delays cellular senescence

Chromosomal instability (CIN) refers to the rate at which cells are unable to properly segregate whole chromosomes, leading to aneuploidy. Besides its prevalence in cancer cells and postulated implications in promoting tumorigenesis, studies in aneuploidy‐prone mouse models uncovered an unanticipate...

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Detalles Bibliográficos
Autores principales: Barroso‐Vilares, Monika, Macedo, Joana C, Reis, Marta, Warren, Jessica D, Compton, Duane, Logarinho, Elsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202060/
https://www.ncbi.nlm.nih.gov/pubmed/32134180
http://dx.doi.org/10.15252/embr.201949248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202060/
https://www.ncbi.nlm.nih.gov/pubmed/32134180
http://dx.doi.org/10.15252/embr.201949248

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