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Multisite EGFR phosphorylation is regulated by adaptor protein abundances and dimer lifetimes

Differential epidermal growth factor receptor (EGFR) phosphorylation is thought to couple receptor activation to distinct signaling pathways. However, the molecular mechanisms responsible for biased signaling are unresolved due to a lack of insight into the phosphorylation patterns of full-length EG...

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Detalles Bibliográficos
Autores principales: Salazar-Cavazos, Emanuel, Nitta, Carolina Franco, Mitra, Eshan D., Wilson, Bridget S., Lidke, Keith A., Hlavacek, William S., Lidke, Diane S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202077/
https://www.ncbi.nlm.nih.gov/pubmed/31913761
http://dx.doi.org/10.1091/mbc.E19-09-0548