An Innovative Sequence-to-Structure-Based Approach to Drug Resistance Interpretation and Prediction: The Use of Molecular Interaction Fields to Detect HIV-1 Protease Binding-Site Dissimilarities

In silico methodologies have opened new avenues of research to understanding and predicting drug resistance, a pressing health issue that keeps rising at alarming pace. Sequence-based interpretation systems are routinely applied in clinical context in an attempt to predict mutation-based drug resist...

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Detalles Bibliográficos
Autores principales: Alves, Nuno G., Mata, Ana I., Luís, João P., Brito, Rui M. M., Simões, Carlos J. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202381/
https://www.ncbi.nlm.nih.gov/pubmed/32411655
http://dx.doi.org/10.3389/fchem.2020.00243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202381/
https://www.ncbi.nlm.nih.gov/pubmed/32411655
http://dx.doi.org/10.3389/fchem.2020.00243

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