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Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21(WAF1)-PKCζ pathway in p16(INK4a)-silenced cells
Mitochondrial dysfunction is linked to age-related senescence phenotypes. We report here the pathway increasing nucleoid remodeling and biogenesis in mitochondria during the senescence of foreskin human diploid fibroblasts (fs-HDF) and WI-38 cells. Replicative senescence in fs-HDF cells increased mi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202532/ https://www.ncbi.nlm.nih.gov/pubmed/32330121 http://dx.doi.org/10.18632/aging.103029 |