Cargando…

Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21(WAF1)-PKCζ pathway in p16(INK4a)-silenced cells

Mitochondrial dysfunction is linked to age-related senescence phenotypes. We report here the pathway increasing nucleoid remodeling and biogenesis in mitochondria during the senescence of foreskin human diploid fibroblasts (fs-HDF) and WI-38 cells. Replicative senescence in fs-HDF cells increased mi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Yun Yeong, Choi, Yeon Seung, Kim, Do Wan, Cheong, Jae Youn, Song, Kye Yong, Ryu, Min Sook, Lim, In Kyoung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202532/ https://www.ncbi.nlm.nih.gov/pubmed/32330121 http://dx.doi.org/10.18632/aging.103029

Ejemplares similares

PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation
por: Heo, Kyung-Sun, et al.
Publicado: (2011)

The p16(INK4a) tumor suppressor controls p21(WAF1) induction in response to ultraviolet light
por: Al-Mohanna, Mai A., et al.
Publicado: (2007)

Novel PKC-ζ to p47(phox) interaction is necessary for transformation from blebbishields
por: Jinesh, Goodwin G., et al.
Publicado: (2016)

Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells
por: Komata, T, et al.
Publicado: (2003)

Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKCζ–p53–p21 signaling pathway
por: Jung, Seung Hee, et al.
Publicado: (2017)

p16(INK4A) Positively Regulates p21(WAF1) Expression by suppressing AUF1-dependent mRNA decay
por: Al-Khalaf, Huda H., et al.
Publicado: (2013)

Rad9 modulates the P21(WAF1 )pathway by direct association with p53
por: Ishikawa, Kazuhiro, et al.
Publicado: (2007)

O-GlcNAc on PKCζ Inhibits the FGF4-PKCζ-MEK-ERK1/2 Pathway via Inhibition of PKCζ Phosphorylation in Mouse Embryonic Stem Cells
por: Miura, Taichi, et al.
Publicado: (2017)

p16(Ink4a) and p21(Cip1/Waf1) promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
por: Okuma, Atsushi, et al.
Publicado: (2017)

Regulations of Reversal of Senescence by PKC Isozymes in Response to 12-O-Tetradecanoylphorbol-13-Acetate via Nuclear Translocation of pErk1/2
por: Lee, Yun Yeong, et al.
Publicado: (2016)

The Distinct Function of p21(Waf1/Cip1) With p16(Ink4a) in Modulating Aging Phenotypes of Werner Syndrome by Affecting Tissue Homeostasis
por: Zhang, Yongjin, et al.
Publicado: (2021)

Clinicopathological Comparison of Adenocarcinoma of Cervix and Endometrium Using Cell Cycle Markers: P16ink4a, P21waf1, and p27Kip1 on 132 Cancers
por: Marican Abu Backer, Farveen, et al.
Publicado: (2011)

p21/WAF1 expression as related to p53, cell proliferation and prognosis in epithelial ovarian cancer
por: Anttila, M A, et al.
Publicado: (1999)

p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6
por: Phalke, Sameer, et al.
Publicado: (2012)

The effects of transferring tumor suppressor gene p16(INK4A) to p16(INK4A)-deleted cancer cells*
por: Lee, Kye Young, et al.
Publicado: (1999)

Cytoplasmic p21(Cip1/WAF1) regulates neurite remodeling by inhibiting Rho-kinase activity
por: Tanaka, Hiroyuki, et al.
Publicado: (2002)

YY1/BCCIP Coordinately Regulates P53-Responsive Element (p53RE)-Mediated Transactivation of p21(Waf1/Cip1)
por: Sui, Yi, et al.
Publicado: (2019)

Mechanisms of MEOX1 and MEOX2 Regulation of the Cyclin Dependent Kinase Inhibitors p21(CIP1/WAF1) and p16(INK4a) in Vascular Endothelial Cells
por: Douville, Josette M., et al.
Publicado: (2011)

PKCζ-dependent upregulation of p27kip1 contributes to oxidative stress induced retinal pigment epithelial cell multinucleation
por: Rajapakse, Dinusha, et al.
Publicado: (2017)

Down-regulation of PKCζ in renal cell carcinoma and its clinicopathological implications
por: Pu, Yeong-Shiau, et al.
Publicado: (2012)

p21/WAF1 expression in human colorectal carcinoma: association with p53, transcription factor AP-2 and prognosis
por: Ropponen, K M, et al.
Publicado: (1999)

Reduced p21(WAF1/CIP1)protein expression is predominantly related to altered p53 in hepatocellular carcinomas
por: Shi, Y-Z, et al.
Publicado: (2000)

Expression of the cell cycle regulation proteins p53 and p21(WAF1) in different types of non-dysplastic leukoplakias
por: VISIOLI, Fernanda, et al.
Publicado: (2012)

Mitomycin C and decarbamoyl mitomycin C induce p53-independent p21(WAF1/CIP1) activation
por: Cheng, Shu-Yuan, et al.
Publicado: (2016)

Transcriptional activation of p21(Waf1) contributes to suppression of HR by p53 in response to replication arrest induced by camptothecin
por: Romanova, Larisa Y., et al.
Publicado: (2018)

Association of PKCζ Expression with Clinicopathological Characteristics of Breast Cancer
por: Yin, Jian, et al.
Publicado: (2014)

Analysis of p53, p16MTS, p21WAF1 and H-ras in archived bladder tumours from workers exposed to aromatic amines.
por: SÃ¸rlie, T., et al.
Publicado: (1998)

Cyclin D1 expression in transitional cell carcinoma of the bladder: correlation with p53, waf1, pRb and Ki67
por: Tut, V M, et al.
Publicado: (2001)

Correlation between expression of p53, p21/WAF1, and MDM2 proteins and their prognostic significance in primary hepatocellular carcinoma
por: Zhang, Mei-Fang, et al.
Publicado: (2009)

The effects of fucodian on senescence are controlled by the p16(INK4a)-pRb and p14(Arf)-p53 pathways in hepatocellular carcinoma and hepatic cell lines
por: MIN, EUN-YOUNG, et al.
Publicado: (2014)

Specific involvement of atypical PKCζ/PKMζ in spinal persistent nociceptive processing following peripheral inflammation in rat
por: Marchand, Fabien, et al.
Publicado: (2011)

The Effect of SIN1 and Microtubules on Insulin Induced PKC ζ Activation
por: Yingying, Xiang, et al.
Publicado: (2017)

Anti-cancer DNA Intercalators cause p53 Dependent Mitochondrial DNA Nucleoid Re-modelling
por: Ashley, Neil, et al.
Publicado: (2009)

Hypermethylation of p16(INK4a) in Korean Non-small Cell Lung Cancer Patients
por: Hong, Young-Seoub, et al.
Publicado: (2007)

Clinical and pathological associations with p53 tumour-suppressor gene mutations and expression of p21WAF1/Cip1 in colorectal carcinoma.
por: Slebos, R. J., et al.
Publicado: (1996)

DNA-PK(CS) binding to p53 on the p21(WAF1/CIP1) promoter blocks transcription resulting in cell death
por: Hill, Richard, et al.
Publicado: (2011)

Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression
por: Ho, Dong Hwan, et al.
Publicado: (2015)

Epigenetic Regulation of p21(cip1/waf1) in Human Cancer
por: Ocker, Matthias, et al.
Publicado: (2019)

Upregulation of p16(INK4A) and Bax in p53 wild/p53-overexpressing crypts in ulcerative colitis-associated tumours
por: Yoshida, T, et al.
Publicado: (2004)

PKCζ and PKMζ are overexpressed in TCF3-rearranged paediatric acute lymphoblastic leukaemia and are associated with increased thiopurine sensitivity
por: Hartsink-Segers, S A, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_edn18rt0i8173p0qum8n5nboom