Shared genetic architecture and casual relationship between leptin levels and type 2 diabetes: large-scale cross-trait meta-analysis and Mendelian randomization analysis

OBJECTIVE: We aimed to estimate genetic correlation, identify shared loci and test causality between leptin levels and type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: Our study consists of three parts. First, we calculated the genetic correlation of leptin levels and T2D or glycemic traits by us...

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Detalles Bibliográficos
Autores principales: Wang, Xinpei, Jia, Jinzhu, Huang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Epidemiology/Health Services Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202746/
https://www.ncbi.nlm.nih.gov/pubmed/32341051
http://dx.doi.org/10.1136/bmjdrc-2019-001140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202746/
https://www.ncbi.nlm.nih.gov/pubmed/32341051
http://dx.doi.org/10.1136/bmjdrc-2019-001140

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