Identification of drug modifiers for RYR1-related myopathy using a multi-species discovery pipeline

Ryanodine receptor type I-related myopathies (RYR1-RMs) are a common group of childhood muscle diseases associated with severe disabilities and early mortality for which there are no available treatments. The goal of this study is to identify new therapeutic targets for RYR1-RMs. To accomplish this,...

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Detalles Bibliográficos
Autores principales: Volpatti, Jonathan R, Endo, Yukari, Knox, Jessica, Groom, Linda, Brennan, Stephanie, Noche, Ramil, Zuercher, William J, Roy, Peter, Dirksen, Robert T, Dowling, James J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202896/
https://www.ncbi.nlm.nih.gov/pubmed/32223895
http://dx.doi.org/10.7554/eLife.52946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202896/
https://www.ncbi.nlm.nih.gov/pubmed/32223895
http://dx.doi.org/10.7554/eLife.52946

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