Loss of the nuclear Wnt pathway effector TCF7L2 promotes migration and invasion of human colorectal cancer cells

The transcription factor TCF7L2 is indispensable for intestinal tissue homeostasis where it transmits mitogenic Wnt/β-Catenin signals in stem and progenitor cells, from which intestinal tumors arise. Yet, TCF7L2 belongs to the most frequently mutated genes in colorectal cancer (CRC), and tumor-suppr...

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Detalles Bibliográficos
Autores principales: Wenzel, Janna, Rose, Katja, Haghighi, Elham Bavafaye, Lamprecht, Constanze, Rauen, Gilles, Freihen, Vivien, Kesselring, Rebecca, Boerries, Melanie, Hecht, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203011/
https://www.ncbi.nlm.nih.gov/pubmed/32203164
http://dx.doi.org/10.1038/s41388-020-1259-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203011/
https://www.ncbi.nlm.nih.gov/pubmed/32203164
http://dx.doi.org/10.1038/s41388-020-1259-7

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