Cargando…

Loss of the nuclear Wnt pathway effector TCF7L2 promotes migration and invasion of human colorectal cancer cells

The transcription factor TCF7L2 is indispensable for intestinal tissue homeostasis where it transmits mitogenic Wnt/β-Catenin signals in stem and progenitor cells, from which intestinal tumors arise. Yet, TCF7L2 belongs to the most frequently mutated genes in colorectal cancer (CRC), and tumor-suppr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wenzel, Janna, Rose, Katja, Haghighi, Elham Bavafaye, Lamprecht, Constanze, Rauen, Gilles, Freihen, Vivien, Kesselring, Rebecca, Boerries, Melanie, Hecht, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203011/ https://www.ncbi.nlm.nih.gov/pubmed/32203164 http://dx.doi.org/10.1038/s41388-020-1259-7

Ejemplares similares

TGFβ1-Induced EMT in the MCF10A Mammary Epithelial Cell Line Model Is Executed Independently of SNAIL1 and ZEB1 but Relies on JUNB-Coordinated Transcriptional Regulation
por: Antón-García, Pablo, et al.
Publicado: (2023)

SMAD4 mutations do not preclude epithelial–mesenchymal transition in colorectal cancer
por: Frey, Patrick, et al.
Publicado: (2021)

SNAIL1-mediated downregulation of FOXA proteins facilitates the inactivation of transcriptional enhancer elements at key epithelial genes in colorectal cancer cells
por: Jägle, Sabine, et al.
Publicado: (2017)

Wnt Effector TCF4 Is Dispensable for Wnt Signaling in Human Cancer Cells
por: Hrckulak, Dusan, et al.
Publicado: (2018)

Dazap2 modulates transcription driven by the Wnt effector TCF-4
por: Lukas, Jan, et al.
Publicado: (2009)

Evolutionary diversification of the canonical Wnt signaling effector TCF/LEF in chordates
por: Torres‐Aguila, Nuria P., et al.
Publicado: (2022)

Transcriptional activity mediated by β-CATENIN and TCF/LEF family members is completely dispensable for survival and propagation of multiple human colorectal cancer cell lines
por: Fröhlich, Janna, et al.
Publicado: (2023)

Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/β-catenin target gene expression
por: Wallmen, Britta, et al.
Publicado: (2012)

Hierarchical Classification of Cancers of Unknown Primary Using Multi-Omics Data
por: Bavafaye Haghighi, Elham, et al.
Publicado: (2019)

The Nuclear Effector of Wnt-Signaling, Tcf1, Functions as a T-Cell–Specific Tumor Suppressor for Development of Lymphomas
por: Tiemessen, Machteld M., et al.
Publicado: (2012)

Current understanding and dispute on the function of the Wnt signaling pathway effector TCF7L2 in hepatic gluconeogenesis
por: Jin, Tianru
Publicado: (2015)

The Wnt Signaling Pathway Effector TCF7L2 Mediates Olanzapine-Induced Weight Gain and Insulin Resistance
por: Li, Ranran, et al.
Publicado: (2018)

Acetylation of Human TCF4 (TCF7L2) Proteins Attenuates Inhibition by the HBP1 Repressor and Induces a Conformational Change in the TCF4::DNA Complex
por: Elfert, Susanne, et al.
Publicado: (2013)

The Wnt Signaling Pathway Effector TCF7L2 Controls Gut and Brain Proglucagon Gene Expression and Glucose Homeostasis
por: Shao, Weijuan, et al.
Publicado: (2013)

Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/β-catenin targets
por: Weise, Andreas, et al.
Publicado: (2010)

Multi-Level Interactions between the Nuclear Receptor TRα1 and the WNT Effectors β-Catenin/Tcf4 in the Intestinal Epithelium
por: Sirakov, Maria, et al.
Publicado: (2012)

The developmental Wnt signaling pathway effector β-catenin/TCF mediates hepatic functions of the sex hormone estradiol in regulating lipid metabolism
por: Tian, Lili, et al.
Publicado: (2019)

Opposing Effects of Tcf3 and Tcf1 Control Wnt-Stimulation of Embryonic Stem Cell Self Renewal
por: Yi, Fei, et al.
Publicado: (2011)

Correction: Multi-Level Interactions between the Nuclear Receptor TRα1 and the WNT Effectors β-Catenin/Tcf4 in the Intestinal Epithelium
Publicado: (2014)

Retraction: Multi-Level Interactions between the Nuclear Receptor TRα1 and the WNT Effectors β-Catenin/Tcf4 in the Intestinal Epithelium
Publicado: (2020)

Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse
por: Haimovici, Aladin, et al.
Publicado: (2022)

The E protein-TCF1 axis controls γδ T cell development and effector fate
por: Fahl, Shawn P., et al.
Publicado: (2021)

TCF1/LEF1 triggers Wnt-dependent chemokine/cytokine-induced inflammation and cadherin pathways to drive T-ALL cell migration
por: Zhao, Pin, et al.
Publicado: (2023)

Clusterin expression can be modulated by changes in TCF1-mediated Wnt signaling
por: Schepeler, Troels, et al.
Publicado: (2007)

Upregulation of TCF21 inhibits migration of adrenocortical carcinoma cells
por: Kremer, Jean Lucas, et al.
Publicado: (2021)

Genetic Variants of Wnt Transcription Factor TCF-4 (TCF7L2) Putative Promoter Region Are Associated with Small Intestinal Crohn's Disease
por: Koslowski, Maureen J., et al.
Publicado: (2009)

lncTCF7 is a negative prognostic factor, and knockdown of lncTCF7 inhibits migration, proliferation and tumorigenicity in glioma
por: Gao, Xiao, et al.
Publicado: (2017)

A Wnt-kinase network alters nuclear localization of TCF-1 in colon cancer
por: Najdi, Rani, et al.
Publicado: (2009)

Temporal Perturbation of the Wnt Signaling Pathway in the Control of Cell Reprogramming Is Modulated by TCF1
por: Aulicino, Francesco, et al.
Publicado: (2014)

Wnt-Mediated Repression via Bipartite DNA Recognition by TCF in the Drosophila Hematopoietic System
por: Zhang, Chen U., et al.
Publicado: (2014)

Structure-Function Analysis of the C-clamp of TCF/Pangolin in Wnt/ß-catenin Signaling
por: Ravindranath, Aditi, et al.
Publicado: (2014)

A functional connectome: regulation of Wnt/TCF-dependent transcription by pairs of pathway activators
por: Freeman, Jamie, et al.
Publicado: (2015)

Correction: Structure-Function Analysis of the C-clamp of TCF/Pangolin in Wnt/ß-catenin Signaling
Publicado: (2014)

Pja2 Inhibits Wnt/β-catenin Signaling by Reducing the Level of TCF/LEF1
por: Song, Yonghee, et al.
Publicado: (2018)

Narrowband UVB treatment induces expression of WNT7B, WNT10B and TCF7L2 in psoriasis skin
por: Assarsson, Malin, et al.
Publicado: (2019)

TCF21 hypermethylation regulates renal tumor cell clonogenic proliferation and migration
por: Gooskens, Saskia L., et al.
Publicado: (2017)

Wnt–β-catenin–Tcf-4 signalling-modulated invasiveness is dependent on osteopontin expression in breast cancer
por: Ravindranath, A, et al.
Publicado: (2011)

The TCF C-clamp DNA binding domain expands the Wnt transcriptome via alternative target recognition
por: Hoverter, Nate P., et al.
Publicado: (2014)

Ubiquitin C-terminal hydrolase37 regulates Tcf7 DNA binding for the activation of Wnt signalling
por: Han, Wonhee, et al.
Publicado: (2017)

VBP1 modulates Wnt/β-catenin signaling by mediating the stability of the transcription factors TCF/LEFs
por: Zhang, Haifeng, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0johj777en8li4ulv47urrspuh