Proteomics-Based Approach Identifies Altered ER Domain Properties by ALS-Linked VAPB Mutation

An ER transmembrane protein, vesicle-associated membrane protein-associated protein B (VAPB), binds to several organelle-resident membrane proteins to mediate ER-organelle tethering. Mutation in amyotrophic lateral sclerosis (ALS) induces protein misfolding and aggregation, leading to ER disorganiza...

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Detalles Bibliográficos
Autores principales: Yamanaka, Tomoyuki, Nishiyama, Risa, Shimogori, Tomomi, Nukina, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203144/
https://www.ncbi.nlm.nih.gov/pubmed/32376919
http://dx.doi.org/10.1038/s41598-020-64517-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203144/
https://www.ncbi.nlm.nih.gov/pubmed/32376919
http://dx.doi.org/10.1038/s41598-020-64517-z

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